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76%) ( 4 The advancement of transfusion and its effect on patient outcomes In the setting of acute hemoglobin reduction, transfusion of packed red blood cells serves as a critical intervention for maintaining adequate oxygen delivery to vital organs, particularly the heart and brain ( There is significant heterogeneity in tissue susceptibility to ischemia across different organ systems ( 2 )–rather than relying solely on a single hemoglobin threshold (43)
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