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“In most of these mice, when we introduced cancer cells as we typically do, there was no trace of a tumor,” said Mahajan, also a research member of Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

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showed that the production of claudin-4 and Zonula Occludens 1 (ZO-1), two TJ proteins, is increased after activation of SSTR 5 and subsequent signaling through the nuclear factor kappa B subunit 1 (NF-κB)—myosin light chain kinase (MLCK)—myosin light chain (MLC) pathway [100]