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Funding This work was supported by the Ministry of Science, Innovation and Universities (PSI2017-83893-R and PID2020-117259RBI00) and the Ministry of Economy and Business (PSI2017-90806-REDT) (Spain)

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A higher density of nigral TH + neurons was found in the animals treated with dual drug loaded NPs, demonstrating that the system was able to cross the blood brain barrier preventing dopaminergic neuronal degeneration