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The role of the carboxyl-terminal tail in inhibiting autophosphorylation and downstream signaling highlights a potential pathway for future drug development, especially in treating patients with c-MET overexpression to prevent excessive activation of the protein and its signaling pathways

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377 Third, imaging biomarkers now quantify peritumoral adipose remodeling in vivo: radiomic texture features from peritumoral adipose tissue on FDG-PET/CT and MRI predict axillary nodal status, neoadjuvant response, and disease progression in BC, thereby noninvasively capturing CAA-linked inflammation and metabolic coupling