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GluK3 receptor tetramers were isolated by gel filtration chromatography (Superose 6 10/300) in a buffer containing 150 mM NaCl, 20 mM Tris (pH 8.0), 0.75 mM n-dodecyl-β-D-maltopyranoside, and 0.03 mM cholesterol hemisuccinate were concentrated to ~1.7 mg/mL (MWCO 100 kDa)

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