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This paper was developed as part of the GBD Collaborator Network and GBD Protocol with support from the GBD Secretariat, IHME and the GBD Collaborator Network under the IHME ID: 4251 (GBD 2023 Substance Use Collaborators)

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Clinical evidence suggests tranexamic acid is well-tolerated in darker skin types when formulated appropriately, though individual patch testing is recommended prior to full-face application given the increased risk of contact dermatitis in melanin-rich skin