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Although we do not yet understand the precise structural basis of this process, the results we present here demonstrate a link between the activation of GABA A Rs and the potentiation of inhibitory synapses not only providing an important insight into the plasticity of inhibition in the brain, but also revealing the potential of the GABA A R to signal its level of activation (desensitization) by engaging with a metabotropic signalling pathway at inhibitory synapses
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Brain glutathione levels—a novel biomarker for mild cognitive impairment and Alzheimer’s disease