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Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice | Oncogene

1-dodecpyrrolidinone

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NO can react with the cysteine of GSH to form GSNO that may be considered an endogenous NO reservoir, which can release it when it reacts with Cu + or with denitrosylating enzymes such as Trx and GSNO reductase (Sengupta and Holmgren, 2013)