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Astrocytic endfeet wrap intraparenchymal blood vessels and release prostaglandins and nitric oxide which can either dilate or constrict blood vessels (Nishida and Okabe, 2007

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185 GM-CSF derived from breast cancer tumor cells can promote ARG1 expression in tumor-infiltrating myeloid cells through STAT3 and p38 MAPK signaling pathways, enhance the function of tumor-infiltrating myeloid cells, and promote the development of immunosuppressive TME (Fig