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PMID: 22463691 | doi:10.1146/annurev-biochem-052110-115718 Mendias CL et al

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When interpreted together with the findings of the STEP 4 withdrawal trial and STEP 1 off-treatment extension study, which both showed weight regain after semaglutide discontinuation (after 20 weeks’ treatment in STEP 4 and 68 weeks’ treatment in STEP 1) 23,24 , these results support the benefit of continued semaglutide treatment for sustained weight loss

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