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Participants were all outpatients and for initial enrollment were required to have a score ≥18 on the 17-item HAM-D and have a history of inadequate response to two or more antidepressants, specifically listed in Section A: Recognized Antidepressants of the Maudsley Treatment Inventory 53 , prescribed at a minimum effective dose for at least 6 weeks, or at least one antidepressant prescribed at the minimum effective dose for at least 6 weeks and a course of evidence-based psychotherapy

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Melanotan-II is not an FDA-approved drug and is supplied for research use only