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The advanced lead 116 elicited high MCHr1 potency (IC 50 = 34 nM) and showed excellent permeability with no efflux (ER = 0.37)
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Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms