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Researchers have found a strong association between HLA-B27 and a perpetual activation of both the innate and the adaptive immune systems, in particular of the IL-23/IL-17 axis and Th1 effector T-cell lineage with the overproduction of tumor necrosis factor-a (TNF-a)

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Nevertheless, serum or urine levels of pentosidine and the ratio of α/β CTX have been reported to predict fracture risk in postmenopausal women, in men and in patients with type 2 diabetes