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Two of the most critical of these functions is to stimulate both glycogenolysis and gluconeogenesis in the liver, which together act to increase circulating blood glucose [85]

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it does not establish that reducing to 0.5 or 1.0 mg will hold the same plateau.⁴ One milligram has direct weight-loss evidence as an assigned treatment arm in type 2 diabetes, while small uncontrolled series suggest that dose reduction or reduced-frequency dosing can sometimes hold a plateau.¹⁰ No trial has established a Semaglutide step-down schedule