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Notably, tumor associated macrophages (TAMs)—the most abundant immune cells in solid cancers regulating immunosuppression, tumor growth, and metastasis formation—have a robust circadian rhythm and at least 10% of their transcriptional activity has been reported to be under circadian regulation 114

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Moreover, we tested the capability of curcumin as a powerful iron chelator to prevent tumor promotion in T51B and RL-34 cells