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Their best candidate exhibits a r 2 change from 200 to 34 mM −1 s −1 which is in a convenient range for intracellular calcium detection (EC 50 = 1.4 µM)

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Donepezil, an acetylcholinesterase inhibitor used in Alzheimer's disease, has been shown to stabilize ferritin structure through high-affinity binding, suggesting a potential role in modulating cerebral iron metabolism beyond its cholinergic effects (103)