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In other words, to obtain a nucleic acid having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted or substituted with another nucleotide, or a number of nucleotides up to 5% of the total nucleotides in the reference sequence may be inserted into the reference sequence

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In a feed-forward inhibition mechanism, c-Myc is also able to activate the expression of the miR17-92 complex of miRNAs, which in turn inhibits the translation of E2F1-3 genes [108]