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As mentioned, these might constitute the BPC 157 selective action in decompression/reperfusion, related to its modulatory effects, at least, on two systems essentially involved in the cytoprotection concept and vascular integrity maintenance, prostaglandin system [40] and NO system [41,42,43,44,45,48,49], and its additional particular interaction with several molecular pathways [6,48,49,50,51,52,53,54,55,56,57,58]

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MAPPs for the identification of immunogenic hotspots of biotherapeutics