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For example, the presence of a greater number of hydroxyl (−OH) groups in epicatechin gallate and epigallocatechin gallate, concerning the non-galloyl tannins (catechin and epicatechin) ( One of the most studied compounds is resveratrol, which has been shown capacity to inhibit the so-called “oxidative burst” (production of O 2 – and H 2 O 2 ), to inhibit the expression of NADPH oxidase, to inhibit the uncoupling of the endothelial nitric oxide synthase (eNOS) ( Free radicals such as reactive oxygen species (ROS) can trigger the production of inflammatory mediators such as the cytosine TNF-α, which in turn can lead to increased oxidative stress, in a cycle that contributes to the genesis of pathologies such as cancer, atherosclerosis, neurodegenerative disorders, among others (Figure 1 summarizes the main antioxidant and anti-inflammatory activities of red wine polyphenols reported in previous studies

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This is why improving bile flow is a direct methylation intervention, not just a digestive one