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Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP-2 and MMP-9 via h19/mir-29b-3p and akt/mtor/autophagy signaling pathways

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ChIP-seq experiments were analyzed using Trimmomatic for trimming (Bolger et al, 2014), Bowtie2 (Langmead and Salzberg, 2012) for aligning to the human genome (hg38), SAMtools (Li et al, 2009) to remove the aligned reads with a mapping quality Q30 and MACS2 for peak calling (Zhang et al, 2008) with default narrow peak calling setting for TFs

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