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Keywords: Lipid metabolism, Insulin resistance, Dyslipidemia, Aging, Oxidative stress, GH/IGF-I axis, Obesity, Mitochondrial dysfunction, Cellular protection Background Consistent data from multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease (CVD), diabetes, and altered metabolic profile of diabetic patients