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Similarly, in this study, where LAD2 cells were incubated with IgE, quercetin inhibited DNP-HSA/IgE-induced Ca 2+ flux, significantly suppressed the DNP-HSA/IgE-induced release of β-hexosaminidase and histamine, and inhibited the DNP-HAS/IgE-induced secretion of IL-13, MCP-1, IL-8, and TNF-α in a concentration-dependent manner (0, 25, 50, 100 μM), as reported in Figure 2, quadrant A and B [10]