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Structurally, the N-terminal binding pocket of MDM2 is hydrophobic and recognizes the canonical p53 TAD motif (Phe19-Trp23-Leu26), which has provided the basis for designing small molecules that occupy this pocket and displace p53 [280]

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Book an appointment Complications of Dysphagia Swallowing difficulties caused by dysphagia can have significant effects on nutrition, hydration, and respiratory health