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Indeed, inhibition of NOX activity by apocynin was found to result in reduction in renal gluconeogenesis via activation of the ERK1/2 pathway in rat proximal tubules exposed to high glucose as well as in Zucker diabetic fatty rats (270), suggesting the implication of NOX-derived ROS in renal glucose regulation

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Yes, not B12 related but recently treated a dog with a previously unopened antibiotic cream that was a couple of years out of date and it worked well

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