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At two weeks post-irradiation, saliva was collected for 15 min after stimulation by intraperitoneal injection of pilocarpine (2 mg/kg, 161-07201, Fujifilm Wako) in PBS, and salivary flow rates were calculated

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We calculated the canonical parallel direction (CPD) by taking the difference between tumour–model pairs and then performing PCA on the resulting difference matrix with the R package irlba ( We took the CPD as the first loading vector

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