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et al, Gene, 46:145-152, (1986), and Hill, D E, et al, Methods Enzymol., 55:559-568, (1987)

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3.4 Checkpoint dysregulation couples immune escape and ferroptosis in Alzheimer’s disease Immune checkpoints play critical regulatory roles in maintaining immune homeostasis in the central nervous system (CNS) and facilitating the clearance of pathological proteins, such as amyloid-β (Aβ) and hyperphosphorylated tau