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Resting platelets also express gp130 on their membranes and in the presence of IL-6 (produced by stressed endothelial cells), platelet-derived IL-6 trans-signaling happens and could be crucial in the development of inflammation within a damaged vessel 39 and in platelet thrombogenicity 40

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(2010) Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis