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In the acidified endosome, ferric iron (Fe 3+ ) readily dissociates from Tf [121,122] and is subsequently reduced to ferrous iron (Fe 2+ ) by NADPH-dependent endosomal ferrireductase Steap3 (six-transmembrane epithelial antigen of the prostate) [123], prior to its transport into the cytosol by H + -coupled endosomal DMT1B-II [124] (see also Figure 5)

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We compared these patients to similar controls without a BS through 1:1 propensity score matching (PSM) for demographics, body mass index (BMI), comorbidities, and medication