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At the mechanistic level, UA was found to decrease the expression of miR-27, and the overexpression of miR-27 was observed to negate the effects of UA on PPAR-γ, thereby identifying miR-27 as a significant mediator

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Glutathione is critical in protecting tissues from oxidative stress and balancing the redox state of the extracellular environment but it can also serve as a source of cysteine for cells [13,105]