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However, another 2025 systematic review and meta-analysis of randomized controlled trials of intratympanic N-acetylcysteine in the prevention of cisplatin-induced ototoxicity, involving collectively 88 cisplatin-based chemotherapy patients, found a significant difference in hearing thresholds between the ear treated with N-acetylcysteine and the control ear (ear not treated with N-acetylcysteine), especially at high frequencies as high as 8000 Hz (141)

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Leukemia 38(9):2072, 2024