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JAM-A orchestrates the spatiotemporal association of scaffold molecules such as ZO-2 and Afadin that associate with Rap activators such as PDZ-GEFs to modulate activity of small GTPases in the Rap and Rho family, in order to regulate barrier function and integrin-dependent cell migration both in vitro and in vivo (Monteiro et al., 2013)

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To investigate the anti-PD activity of H