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The use of targeted exome sequencing (TES) to perform genetic diagnosis of 60 genes from patients with congenital anomalies of the kidneys and urinary tract (CAKUT) identified pathogenic nucleotide variants of five known pathogenic genes: HNF1B, PAX2, EYA1, UPK3A, and FRAS1 [196]

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Furthermore, Wnt proteins carried by exosomes have been shown to promote β-catenin translocation into the nucleus of endothelial cells, activating downstream effector molecules [98]