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Animal and cellular experiments have shown that curcumin can bind to TLRs and participate in regulating downstream inflammatory signaling pathways such as MAPK, NF-ΞΊB, and AP-1, significantly reducing levels of inflammatory mediators such as IL-1Ξ², IL-6, TNF-Ξ±, NO, and iNOS, thus achieving anti-inflammatory effects [29,65]
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