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Why B12 Deficiency Is So Common Low Vitamin B12 levels may occur due to: Vegetarian or vegan diets Poor gastrointestinal absorption Aging and decreased nutrient absorption Long-term use of antacids Frequent antibiotic use Digestive or autoimmune conditions Reduced intrinsic factor production with age Because oral supplements are not always absorbed efficiently, injectable B12 may provide more consistent support for patients experiencing symptoms of deficiency

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However, challenges such as poor bioavailability, complex multi-component formulations, and lack of standardization still hinder widespread use