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The Atg12-Atg5 complexes subsequently associate with the Atg16L protein

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However, a potentially transformative approach is being advanced to create axon guidance paths via factors secreted by host cells transfected with precise spatial precision (via stereotaxic microinjection) to overexpress growth factors, creating chemotaxic gradients to drive long-distance, targeted axonal outgrowth from endogenous and/or transplanted cells in the CNS