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In particular, a decrease in the activity of the 2-oxoglutarate (α-ketoglutarate) dehydrogenase (OGDH or KGDH) is found in PD brains (Figure 2.8) [109]

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When Nicotine Enters Your System: Rapid absorption: Nicotine reaches your brain within seconds of inhalation Receptor binding: It attaches to nicotinic acetylcholine receptors Neurotransmitter release: This triggers the release of dopamine, norepinephrine, and other chemicals Physical effects: Increased heart rate, blood pressure, and alertness Addiction pathway: The dopamine release creates the potential for dependence When Nicotinic Acid Enters Your System: Metabolic conversion: Your body converts it into NAD+ (nicotinamide adenine dinucleotide) Energy production: NAD+ is crucial for cellular respiration and ATP synthesis DNA maintenance: It supports DNA repair mechanisms Cellular health: Helps maintain the integrity of skin, nerves, and digestive system No addiction potential: It doesn’t interact with reward pathways in the brain Smoking Cessation vs Essential Nutrition In medical contexts, nicotine appears in carefully controlled forms