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Total Parenteral Nutrition (TPN)

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In vitro mammalian cell gene mutation test (HPRT) OECD 476 Typically using Chinese hamster ovary (CHO) or lung (V79) fibroblasts, this test identifies HPRT gene mutations induced by test substances, which impair the cells' ability to metabolize analogs like 6-thioguanine (TG), preventing growth or proliferation in media containing these compounds