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Glial cells including microglia and astrocytes are non-neuronal populations in the central nervous system that function to maintain homeostasis, provide support, and protection, which are both involved in the innate and adaptive immune system (Herculano-Houzel, 2014

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Considering the profound impacts of HIF-1 α on cancer progression via gene expression and the unsatisfactory efficacy of chemotherapy, there has been enormous growing interest in the biology of HIF-1 α pathway and the development of direct or indirect HIF-1 inhibitors