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There was an increase in the concentration of charged amino acids such as L-arginine and L-citruline (metabolism of arginine), polar amino acids such as L-serine, and the apolar residue L-valine

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While significant progress has been made in understanding the role of oxidative stress and antioxidants in impaired bone healing associated with T2DM, further studies are warranted to optimise antioxidant dosages, treatment durations, formulations and delivery methods to promote maximum efficacy and to better understand the specific mechanisms through which antioxidants modulate bone healing in the context of T2DM

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